|
Document Type |
: |
Article In Journal |
|
Document Title |
: |
Effect of cannabinoids on synaptic transmission in the rat hippocampal slice is temperature-dependent. Effect of cannabinoids on synaptic transmission in the rat hippocampal slice is temperature-dependent. |
|
Document Language |
: |
English |
|
Abstract |
: |
Al-Hayani A, Davies SN.
Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland, UK.
We have previously reported that the synthetic cannabinoid R-(+)-[2,3-dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazin-yl]-(1-naphthalenyl)methanone mesylate (WIN55,212-2) causes a selective inhibition of paired pulse depression of population spikes recorded from the CA1 region of rat hippocampal slices maintained at 28-30 degrees C. We now show that this effect is highly temperature-dependent and that WIN55,212-2 actually increases paired pulse depression of population spikes recorded from slices maintained at 35 degrees C. This temperature dependence was found to correlate with the effects of the known gamma-amino butyric acid (GABA)-uptake inhibitors, nipecotic acid and guvacine, which were without effect at 28-30 degrees C, but increased paired pulse depression at 35 degrees C. The results show that the effects of cannabinoids on synaptic transmission in the hippocampal slice are highly temperature-dependent and it is suggested that this is due to the presence of increased GABA uptake at higher temperatures.
PMID: 12020681 [PubMed - indexed for MEDLINE] |
|
ISSN |
: |
12020681 |
|
Journal Name |
: |
Eur J Pharmacol |
|
Volume |
: |
3 |
|
Issue Number |
: |
1-2 |
|
Publishing Year |
: |
2002 AH
2002 AD |
|
Article Type |
: |
Article |
|
Added Date |
: |
Saturday, March 20, 2010 |
|
Researchers
| عبدالمنعم اللحياني | Al-Hayani, Abdel-Moneim | Researcher | Doctorate | |
|