Document Details

Document Type : Article In Journal 
Document Title :
Study of ochratoxin A as an nvironmental risk that causes renal injury in breast-fed Egyptian infants
Study of ochratoxin A as an nvironmental risk that causes renal injury in breast-fed Egyptian infants
 
Document Language : English 
Abstract : Ochratoxin A (OTA) constitutes a real human threat. Its presence in human milk has previously been reported in different countries. This study is the first Egyptian report on the presence of OTA in both mothers’ milk and infants’ sera, addressing its correlation with infants’ kidney functions, which was not previously addressed in the literature. Fifty healthy breast-lactating mothers and their infants who were exclusively breast-fed for at least 4 months were included. All of them were subjected to a thorough laboratory evaluation including determination of OTA concentration by high-performance liquid chromatography. Thirty-six mothers (72%) and their infants had been contaminated with OTA. Univariate analysis showed that the presence of OTA was associated with significantly higher levels of urinary b2 microglobulin and microalbuminuria. Multivariate logistic regression analysis showed that there was a significant correlation between a higher OTA level in infants’ sera and the degree of microalbuminuria. Mothers and their infants in our locality are exposed to a high OTA contamination rate (72%). To establish the role of OTA in causation of future renal dysfunction for infants, large controlled studies are warranted. 
ISSN : 0931-041X 
Journal Name : Pediatr Nephrol 
Volume : 1 
Issue Number : 21 
Publishing Year : 1426 AH
2006 AD 
Article Type : Article 
Added Date : Saturday, May 15, 2010 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
أسامة جابرGaber, Osama ResearcherDoctorate 

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