Document Details Document Type : Article In Journal  Document Title : Malignant eccrine poroma Malignant eccrine poroma   Document Language : English  Abstract : Benign eccrine poroma arises from the intraepidermal portion of the eccrine gland duct. Malignant transformation is rare and should be suspected when these lesions present with pain, bleeding or itching. We report a 44-year-old male patient who presented primarily with a lesion diagnostic of benign eccrine poroma of the right foot sole with no clear evidence of malignancy, which was incompletely excised, followed 5 months later by local recurrence, ulceration, occasional bleeding and right inguina11ymphadenopathy. Incomplete excision of the primary tumor as well as excision of a skin lesion on the right knee joint revealed malignant eccrine poroma with aggressive histology, lymphovascular and perineural invasion. Investigations revealed no evidence of distant metastasis. This tumor might be malignant at the first presentation, which was not confirmed histopathologically considering the short duration of only 5 months for malignant transformation. The patient received 3 cycles of Docetaxel (Taxotere), Cisplatin combination chemotherapy with partial response. The management of metastatic malignant eccrine poroma is difficult. It has proven resistant to many chemotherapeutic agents and radiotherapy.  ISSN : 1110-5607  Journal Name : Saudi Med J  Volume : 26  Issue Number : 5  Publishing Year : 1426 AH 2005 AD  Article Type : Article  Added Date : Saturday, January 15, 2011  Researchers Researcher Name (Arabic) Researcher Name (English) Researcher Type Dr Grade Email محمود الاحول AI-Ahwal, Mahmoud Researcher Doctorate   Files File Name Type Description  28621.doc doc   Back To Researches Page